Endocrine Abstracts

Background: Patients with metastatic carcinoid disease confer a risk for carcinoid syndrome, characterized by hemodynamic instability and syncope. While the physiologic mechanisms linking carcinoid tumor metastases to impaired blood pressure regulation are not well understood, this may be attributed to changes in autonomic function, which is a key regulator of blood pressure. We hypothesize that metastatic carcinoid disease induces autonomic dysfunction. To test this, we longi...

Background: Neuroendocrine tumors that release prostaglandins and biogenic amines that can impact cardiac function. In consequence, patients with carcinoid liver metastases are at risk for carcinoid heart disease. This is primarily characterized by fibrosis in the heart that leads to plaques on the valvular cusps, leaflets and walls of the atrium and ventricles leading to a thickened right heart with regurgitation. Interestingly, 50-80% of patients with carcinoid heart disease...

Introduction: The SARS-CoV-2 virus has severely affected humanity. The disease causes pneumonia which may be severe. In many cases, patients, especially if there are comorbidities, may have a fatal outcome. The disease affects all organs and the variability of its manifestations has attracted intense scientific interest. Aim: The aim of the study was to describe the case of a patient who developed subacute thyroiditis after infection with the SARS-CoV-2 ...

Background: Thyroid dysfunctions are among the most common immune-related adverse events (irAEs) following the administration of immune checkpoint inhibitors (ICIs) for malignancies. The pathogenesis of thyroid irAEs remains unclear and the clinical course can be multifaceted.Aim: Aims of this study were a) to describe the incidence and the clinical course of thyroid irAEs b) to determine the association between thyroid irAEs and overall survival (OS).</...

Background: Although papillary thyroid carcinoma (PTC) is considered to have an excellent prognosis, some more aggressive variants have been identified that show reduced overall survival rates. Besides from the diffuse sclerosing, tall cell, columnar cell, and solid variant, the hobnail variant was newly recognized as one of these aggressive forms, affecting recurrence, metastasis, and overall survival rates.Methods: We performed a systematic review and ...

Introduction: MODY 5 is a rare form of autosomal dominant monogenic diabetes with a broad phenotypical spectrum that occurs with pancreatic and extra-pancreatic clinical manifestations, such as: malformation and dysfunction of the pancreas, nephrourologic anomalies, impaired renal function, hepatopathy and neurocognitive defects. It is caused by a mutation of the gene encoding hepatocyte nuclear transcription factor 1 beta (HNF1β).Case 1: M...

A 52-year man came to Emergency Department with Atrial Fibrillation with rapid ventricular response due to amiodarone induced thyrotoxicosis (AIT). The patient was found tachi-arrhythmic (153 beats per minute), tachypnoic (27 breaths per minute) and with intense hyperidrosis. His first blood test documented thyroid stimulating hormone (TSH) <0.01 mUI/l, free triiodothyronine (fT3) 20.0 pmol/l and free thyroxine (fT4) over 100 pmol/l. Thyroid ultrasonography revealed an enl...

Background: Denosumab (DMAb) and zoledronic acid (ZA) are potent, anti-resorptive agents used to treat patients with osteoporosis. It has been suggested that they increase parathyroid hormone (PTH) levels in response to their antiresorptive effect, and that PTH elevation might be responsible for DMAb modeling actions on bone. The timeline and magnitude of PTH elevation post-DMAb and ZA has not been characterized in a large patient population.Objective: T...

Introduction: Alcohol use disorder AUD causes high socio-economic costs and has a detrimental impact on health globally, being considered a key risk factor for non-communicable diseases. In Switzerland, four substances are currently approved for treatment of AUD, with varying effects. Taking into consideration the complex nature of the disease and the heterogeneity of affect patients, it becomes evident that there is need for new treatment targets. A body of preclinical studie...

Rationale and aim: The incidence of intracranial aneurysms (IA) appears increased in patients with PAs/PitNETs. Changes in hemodynamics and vascular structure secondary to mass effect, inflammation, and hormonal changes (primarily, GH hypersecretion) have been suggested as risk factors. Study aim was to define typical features, timing of occurrence and treatment, and identify risk factors in patients with PA/PitNET and IA.Patients and methods: Data of 57...